Methoxyflurane
Methoxyflurane is a halogenated ether anesthetic agent historically used for general anesthesia during surgical procedures. It acts as a central nervous system depressant, producing sedation, analgesia, and immobility. Due to concerns about nephrotoxicity, its use has been significantly restricted in many countries, though it remains available in some regions for short-term pain management.
Methoxyflurane is an inhaled analgesic/anesthetic that has been largely replaced by safer alternatives due to kidney toxicity concerns but is still used for short-term pain relief in some settings.
Key facts at a glance
- ATC
- N02BG09
- RxNorm
- 6857
- Generic
- Methoxyflurane
- Class
- atc-n02
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- nasal
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Short-term treatment of moderate to severe pain, particularly in emergency medicine, procedural analgesia, and labor (where available). Its use has declined significantly due to safety concerns, and it has been withdrawn from many markets worldwide.
Methoxyflurane is a volatile liquid that, when inhaled, produces general anesthetic effects by depressing the central nervous system. It provides both sedation and analgesia through its action on neuronal ion channels and neurotransmitter systems.
Carries significant risk of dose-dependent nephrotoxicity (kidney damage), particularly with prolonged or repeated use. Associated with hepatotoxicity and malignant hyperthermia in susceptible individuals. Requires appropriate monitoring and should only be used where benefits justify the risks. Strictly contraindicated in patients with known renal impairment or history of hepatitis.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 29, 2026. · Read our editorial policy