Methscopolamine
Methscopolamine is an anticholinergic medication used to treat gastrointestinal conditions like peptic ulcers and irritable bowel syndrome by blocking acetylcholine receptors.
An anticholinergic medication that reduces stomach acid and GI motility for treating ulcers and IBS.
Key facts at a glance
- ATC
- A03BB03
- RxNorm
- 89785
- Generic
- Methscopolamine
- Class
- atc-a03
- Brands
- Pamine
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 2.5-5mg before meals and at bedtime
- Maximum
- consult physician
- Frequency
- 3-4 times daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 2.5mg before meals
- Maximum
- consult physician
- Frequency
- 3 times daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 2.5mg before meals
- Maximum
- consult physician
- Frequency
- twice daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
7 groupspregnancy
first trimesteravoid if possible
avoid use during pregnancy unless benefits significantly outweigh risks
regular prenatal monitoring
Use with caution and monitor for adverse effects.
pregnancy
third trimesteravoid if possible
avoid close to delivery due to potential effects on uterine activity
fetal monitoring and uterine activity monitoring
Use with caution and monitor for adverse effects.
lactation
not recommendedcontraindicated
do not use while breastfeeding - drug may be excreted in breast milk
monitor infant for anticholinergic symptoms
Use of this medication in this population requires careful consideration of risks and benefits.
pediatric_age
children under 12not recommended
not recommended for children under 12 years of age
not applicable
Use of this medication in this population requires careful consideration of risks and benefits.
geriatric
over 65reduce dose
use lower initial dose and titrate slowly - monitor for confusion and urinary retention
closely monitor for anticholinergic effects cognitive changes and urinary retention
Use with caution and monitor for adverse effects.
renal_impairment
moderate to severereduce dose and extend interval
use with caution in renal impairment - dose reduction recommended
monitor renal function and adjust dose accordingly
Use with caution and monitor for adverse effects.
hepatic_impairment
moderate to severereduce dose
use with caution in hepatic impairment - start with lower dose
monitor liver function tests and for signs of toxicity
Use with caution and monitor for adverse effects.
Statistics and clinical data
Commonly prescribed since
General prescribing information for Methscopolamine (Pamine)
Drug class
Drug class information for Methscopolamine
Common uses
Common therapeutic uses for Methscopolamine
Mechanism of action
Primary pharmacological mechanism
Treatment of peptic ulcers, irritable bowel syndrome, and other gastrointestinal conditions associated with excessive secretions and smooth muscle spasms. May also be used for motion sickness and other conditions requiring reduced parasympathetic activity.
Blocks muscarinic acetylcholine receptors in smooth muscle and exocrine glands. This reduces gastric acid secretion, decreases gastrointestinal motility, and reduces other parasympathetic-mediated secretions throughout the body.
May cause dry mouth, blurred vision, constipation, and urinary retention. Contraindicated in patients with glaucoma, urinary obstruction, or severe ulcerative colitis. Use with caution in elderly patients and those with cardiac conditions. May interact with other anticholinergic medications and certain antidepressants.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy