Methyl 5-Aminolevulinate
Methyl 5-Aminolevulinate is a photosensitizing prodrug used in photodynamic therapy for certain dermatological conditions. When applied topically and exposed to specific wavelengths of light, it generates reactive oxygen species that selectively destroy abnormal cells. This medication is primarily used for treating actinic keratosis and certain superficial skin cancers.
A topical photosensitizing agent used in photodynamic therapy for treating certain pre-cancerous and cancerous skin conditions.
Key facts at a glance
- ATC
- L01XD03
- RxNorm
- 337068
- Generic
- Methyl 5-Aminolevulinate
- Class
- atc-l01
- Brands
- Metvixia
- Availability
- rx
- Lactation
- unknown
- Routes
- topical
- Forms
- cream
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used for photodynamic therapy of actinic keratosis (precancerous skin lesions) and superficial basal cell carcinoma when other treatments may not be suitable. Applied topically by healthcare professionals in clinical settings.
After topical application, methyl 5-aminolevulinate is metabolized to protoporphyrin IX, a photosensitive compound that preferentially accumulates in abnormal cells. When illuminated with red light at specific wavelengths, protoporphyrin IX generates cytotoxic reactive oxygen species that destroy the targeted cells through oxidative damage.
Strict photosensitivity precautions required - patients must avoid sunlight and bright indoor light on treated areas for a period after application. Application should only be performed by qualified healthcare professionals. Common side effects include local skin reactions such as burning, stinging, redness, and crusting at the application site. Contraindicated in patients with porphyria or known hypersensitivity to the compound.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy