Methyldopa
Methyldopa is a centrally-acting antihypertensive medication used to treat high blood pressure. It works by stimulating alpha-2 adrenergic receptors in the brain, which reduces sympathetic outflow and lowers blood pressure. Methyldopa is particularly notable as one of the few antihypertensive agents considered relatively safe for use during pregnancy.
Methyldopa is a blood pressure medication that acts centrally in the brain and is commonly used to treat hypertension, especially in pregnant patients.
Key facts at a glance
- ATC
- C02AB01
- RxNorm
- 6876
- Generic
- Methyldopa
- Class
- atc-c02
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet, capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Methyldopa is primarily used to treat hypertension (high blood pressure). It is considered a first-line option for managing high blood pressure during pregnancy due to its established safety profile for both mother and fetus.
Methyldopa acts centrally in the brain by stimulating alpha-2 adrenergic receptors. This leads to decreased sympathetic nervous system activity, resulting in reduced heart rate and vasodilation, which ultimately lowers blood pressure.
Common side effects include drowsiness, dry mouth, and orthostatic hypotension. Liver function should be monitored periodically as hepatotoxicity can rarely occur. Methyldopa may cause positive Coombs test and interfere with certain laboratory tests.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy