Methysergide
Methysergide is an ergot derivative that acts as a serotonin antagonist used primarily for the prevention of migraine headaches. It is typically prescribed when other migraine preventive treatments have been ineffective, and works by blocking serotonin receptors in blood vessels and the brain.
Methysergide is a migraine prevention medication that blocks serotonin receptors but has been largely replaced due to serious side effects.
Key facts at a glance
- ATC
- N02CA04
- RxNorm
- 6911
- Generic
- Methysergide
- Class
- atc-n02
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Methysergide is used for the prophylaxis (prevention) of migraine and cluster headaches, particularly in patients who experience frequent or severe attacks that do not respond adequately to other treatments.
As a serotonin antagonist, methysergide blocks serotonin receptors (particularly 5-HT2 receptors), which helps prevent the vasoconstriction and inflammatory responses associated with migraine attacks.
Due to risk of serious adverse effects including retroperitoneal, pleuropulmonary, and cardiac fibrosis with long-term use, treatment requires regular monitoring and periodic drug holidays. It is contraindicated in patients with cardiovascular disease, pregnancy, and concurrent use with other ergot derivatives or potent CYP3A4 inhibitors.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy