Metyrapone
Metopirone (metyrapone) is a diagnostic medication primarily used to test hypothalamic-pituitary-adrenal (HPA) axis function. It works by temporarily blocking cortisol production, allowing doctors to determine if adrenal insufficiency is caused by primary adrenal failure or secondary to pituitary/hypothalamic dysfunction. It is typically used in hospital or clinical settings under medical supervision.
Metopirone is a diagnostic agent used to evaluate adrenal gland function by temporarily suppressing cortisol production.
Key facts at a glance
- RxNorm
- 203002
- Generic
- Metopirone
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used as a diagnostic test for adrenal insufficiency to differentiate between primary adrenal failure (Addison's disease) and secondary insufficiency due to pituitary or hypothalamic dysfunction. May also be used in managing Cushing's syndrome in certain cases.
Inhibits 11β-hydroxylase, the enzyme responsible for converting 11-deoxycortisol to cortisol in the adrenal gland. By blocking this step, it reduces cortisol production and allows assessment of the pituitary's ability to respond by increasing ACTH.
Should only be administered in settings where cortisol levels can be measured. Contraindicated in patients with primary adrenal insufficiency as it may cause acute adrenal crisis. Common side effects include nausea, dizziness, and headache. Must be discontinued before and during surgery or acute stress.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy