Metyrapone
Metyrapone is a medication that inhibits the enzyme 11β-hydroxylase in the adrenal cortex, reducing the production of cortisol and corticosterone. It is primarily used for diagnostic testing of pituitary function and in the management of Cushing's syndrome when other treatments are not suitable.
Metyrapone reduces cortisol production by blocking an enzyme in the adrenal gland and is used for pituitary function testing and managing excess cortisol conditions.
Key facts at a glance
- ATC
- V04CD01
- RxNorm
- 6923
- Generic
- Metyrapone
- Class
- atc-v04
- Brands
- Metopirone
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used for diagnosis of pituitary insufficiency (ACTH stimulation test), differential diagnosis of Cushing's syndrome, and management of endogenous Cushing's syndrome when surgery has failed or is not feasible.
Metyrapone inhibits 11β-hydroxylase, blocking the final step of cortisol synthesis in the adrenal cortex. This reduces cortisol production, removing cortisol's negative feedback on the pituitary and causing ACTH levels to rise.
Should be used with caution in patients with adrenal insufficiency or hepatic impairment. May cause hypocortisolism, hypotension, or GI disturbances. Not recommended during pregnancy unless clearly needed. Drug interactions possible with CYP450 inducers/inhibitors.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy