Mexiletine
Mexiletine is an oral antiarrhythmic medication used to treat and prevent certain types of irregular heartbeats, particularly ventricular arrhythmias. It works by blocking sodium channels in cardiac tissue, which helps stabilize the heart's electrical activity and maintain normal rhythm. This medication is typically reserved for patients when other antiarrhythmic treatments have not been effective or are not tolerated.
Mexiletine is a Class IB antiarrhythmic used to treat ventricular arrhythmias by blocking sodium channels in the heart.
Key facts at a glance
- ATC
- C01BB02
- RxNorm
- 6926
- Generic
- Mexiletine
- Class
- atc-c01
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule, solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Mexiletine is used to treat ventricular arrhythmias, including ventricular tachycardia and symptomatic premature ventricular contractions, when other antiarrhythmic medications have not been effective or tolerated.
Mexiletine is a Class IB antiarrhythmic that blocks voltage-gated sodium channels in cardiac myocytes. This reduces the rate of phase 0 depolarization, slows conduction velocity, and stabilizes cardiac cell membranes, helping to prevent abnormal electrical rhythms.
Common side effects include nausea, vomiting, heartburn, dizziness, tremor, and nervousness. Regular monitoring with ECG and liver function tests may be needed. Should be used with caution in patients with heart failure, liver disease, or seizure disorders. Dose adjustments may be necessary when used with other medications affecting liver enzymes.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy