Mianserin
Mianserin is a tetracyclic antidepressant that works by blocking alpha-2 adrenergic receptors and certain serotonin receptors, thereby increasing the availability of norepinephrine and serotonin in the brain. It is primarily prescribed for the treatment of major depressive disorder and is particularly useful in patients who have not responded to other antidepressants.
Mianserin is a tetracyclic antidepressant used to treat major depressive disorder by increasing norepinephrine and serotonin activity in the brain.
Key facts at a glance
- ATC
- N06AX03
- RxNorm
- 6929
- Generic
- Mianserin
- Class
- atc-n06
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Mianserin is indicated for the treatment of major depressive disorder. It may be particularly beneficial for patients experiencing depression with anxiety symptoms or sleep disturbances due to its sedating properties.
Mianserin works as a tetracyclic antidepressant by antagonizing alpha-2 adrenergic autoreceptors and heteroreceptors, as well as blocking 5-HT2 serotonin receptors. This dual action increases the release of norepinephrine and serotonin in the brain, helping to improve mood and reduce depressive symptoms.
Mianserin may cause drowsiness, especially when initiating treatment, and is often taken at bedtime. Rare but serious side effects include blood dyscrasias, requiring regular blood monitoring in some patients. It generally has fewer anticholinergic effects than older tricyclic antidepressants. Patients should be monitored closely for worsening depression or suicidal thoughts, particularly when starting therapy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy