Mifepristone
Mifepristone is a synthetic steroid medication that acts as a progesterone receptor antagonist at low doses and a glucocorticoid receptor antagonist at higher doses. It is primarily used for medical termination of early pregnancy and in the management of Cushing's syndrome.
A progesterone receptor blocker used for medical abortion and managing excess cortisol conditions.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- G03XB01
- RxNorm
- 6964
- Generic
- Mifepristone
- Class
- atc-g03
- Brands
- Korlym, Mifeprex
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Medical termination of early pregnancy (up to 10 weeks gestation), management of Cushing's syndrome in patients with type 2 diabetes or glucose intolerance, and softening and dilation of the cervix before surgical procedures.
Blocks progesterone receptors in the uterus, causing decidual breakdown, cervical softening, and increased uterine sensitivity to prostaglandins. At higher doses, antagonizes glucocorticoid receptors, reducing cortisol effects in conditions like Cushing's syndrome.
Must be used under medical supervision, typically with misoprostol for pregnancy termination. Contraindicated in ectopic pregnancy, chronic adrenal failure, and certain bleeding disorders. Common side effects include abdominal pain, cramping, and vaginal bleeding.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy