Ergotamine/Caffeine
Migergot is a combination medication containing ergotamine tartrate and caffeine, used to treat acute migraine and cluster headache episodes. The ergotamine component causes vasoconstriction of cranial blood vessels while caffeine enhances its absorption and adds additional vasoconstrictive effects. This medication is specifically indicated for patients experiencing moderate to severe migraine attacks.
Migergot is a prescription combination drug used to treat acute migraine and cluster headaches by constricting cranial blood vessels.
Key facts at a glance
- RxNorm
- 218377
- Generic
- Migergot
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Acute treatment of migraine attacks with or without aura, and episodic treatment of cluster headaches in adults.
Ergotamine tartrate acts on serotonin (5-HT1B/1D) and dopamine receptors to cause vasoconstriction of cranial blood vessels, reducing migraine pain. Caffeine enhances ergotamine absorption and contributes additional vasoconstrictive activity.
Contraindicated in patients with cardiovascular disease, uncontrolled hypertension, or peripheral vascular disease. Should not be used during pregnancy or with CYP3A4 inhibitors. Risk of medication-overuse headache with frequent use. Associated with rare but serious ergotism and fibrotic complications with prolonged use.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy