Milbemycin
Milbemite is a prescription veterinary medication used to treat ear mite infestations in cats and dogs. It contains the active ingredient milbemycin oxime, which is an antiparasitic agent effective against Otodectes cynotis mites. This topical treatment is applied directly to the ear canal to eliminate mite infections.
Milbemite is a topical ear mite treatment for dogs and cats that kills parasites by disrupting their nervous system.
Key facts at a glance
- RxNorm
- 545169
- Generic
- Milbemite
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Milbemite is indicated for the treatment of ear mite (Otodectes cynotis) infestations in cats and dogs. Ear mites are highly contagious parasites that cause irritation, itching, and inflammation in the ear canal, often leading to head shaking, scratching at the ears, and dark discharge.
Milbemite contains milbemycin oxime, which is a macrocyclic lactone that works by enhancing the release of the neurotransmitter gamma-aminobutyric acid (GABA) at nerve synapses in parasites. This causes paralysis and death of the mites.
Milbemite is for veterinary use only and should be prescribed by a veterinarian. It is applied topically to the ear canal. Possible side effects may include mild irritation at the application site. Pet owners should follow dosing instructions carefully and avoid contact with eyes. Complete the full course of treatment even if symptoms improve.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy