Milnacipran
Milnacipran is a serotonin-norepinephrine reuptake inhibitor (SNRI) used primarily for the treatment of fibromyalgia. It works by increasing the levels of norepinephrine and serotonin in the brain through reuptake inhibition, though its exact mechanism for pain relief is not fully understood.
Milnacipran is an SNRI antidepressant primarily used to treat fibromyalgia pain.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- N06AX17
- RxNorm
- 588250
- Generic
- Milnacipran
- Class
- atc-n06
- Brands
- Savella
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Fibromyalgia syndrome in adults
Potent inhibitor of neuronal norepinephrine and serotonin reuptake, increasing these neurotransmitters in the brain. The exact mechanism for its central pain inhibitory action is unknown.
As an SNRI, milnacipran affects both serotonin and norepinephrine systems. Use with caution in patients with cardiovascular disease, hypertension, or history of seizures. Monitor for suicidal ideation, especially in younger patients.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy