Misoprostol
Misoprostol is a PGE1 analog used to prevent gastric ulcers in patients taking NSAIDs by reducing acid secretion and increasing protection.
Misoprostol is a stomach-protecting medication often combined with NSAIDs to prevent gastric ulcers.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- A02BB01
- RxNorm
- 42331
- Generic
- Misoprostol
- Class
- atc-a02
- Brands
- Cytotec, Arthrotec
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention of NSAID-induced gastric and duodenal ulcers, treatment of peptic ulcer disease, and medical termination of early pregnancy (off-label). In this combination product, it protects the stomach lining from damage caused by diclofenac.
Misoprostol is a synthetic prostaglandin E1 analog that binds to prostaglandin receptors in the stomach. It reduces gastric acid secretion, increases bicarbonate and mucus production, and improves blood flow to the gastric mucosa, creating a protective barrier against NSAID-induced damage.
Contraindicated in pregnancy due to risk of uterine contractions. Common side effects include diarrhea, abdominal pain, and nausea. Should not be used by patients with hypersensitivity to prostaglandins. Effective contraception is recommended during treatment. May reduce the effectiveness of some medications and should be used with caution in patients with cardiovascular disease.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy