Colchicine
Mitigare is a brand-name medication containing colchicine, used primarily for the treatment and prevention of acute gout flares and for managing familial Mediterranean fever (FMF). It is an anti-inflammatory agent that works by inhibiting microtubule polymerization, which reduces the migration and activity of inflammatory cells involved in the gout process. Due to its narrow therapeutic index, careful dosing and monitoring are essential.
Mitigare is a brand-name colchicine medication used to treat acute gout flares and familial Mediterranean fever.
Key facts at a glance
- RxNorm
- 1550941
- Generic
- Mitigare
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Mitigare is FDA-approved for the treatment of acute gout flares and for the prophylactic (preventive) treatment of gout flares. It is also used to manage familial Mediterranean fever (FMF), a hereditary inflammatory condition.
Mitigare contains colchicine, which binds to tubulin and inhibits microtubule polymerization. This disrupts neutrophil migration, phagocytosis, and the release of inflammatory mediators, thereby reducing the inflammatory response associated with gout and FMF.
Mitigare has a narrow therapeutic index, meaning the difference between effective and toxic doses may be small. Common side effects include gastrointestinal symptoms such as nausea, vomiting, and diarrhea. Drug interactions are possible, particularly with strong CYP3A4 and P-glycoprotein inhibitors. Dose adjustments may be necessary for patients with renal or hepatic impairment. Patients should follow prescribed dosing instructions carefully and report any signs of toxicity promptly.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy