Mitomycin
Mitomycin is a chemotherapy medication classified as an antineoplastic agent that works by inhibiting DNA synthesis in rapidly dividing cells. It is primarily used in the treatment of various cancers, including cancers of the stomach, pancreas, bladder, breast, and lung, as well as certain ophthalmic procedures.
Mitomycin is an alkylating chemotherapy agent used to treat various cancers by interfering with cancer cell DNA reproduction.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- L01DC03
- RxNorm
- 632
- Generic
- Mitomycin
- Class
- atc-l01
- Brands
- Mitosol, Mutamycin, Jelmyto, Zusduri
- Availability
- rx
- Lactation
- unknown
- Routes
- ophthalmic
- Forms
- solution, injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used to treat adenocarcinoma of the stomach and pancreas, breast cancer, bladder cancer, non-small cell lung cancer, and cervical cancer. Also utilized in ophthalmology for glaucoma filtering surgery and for superficial bladder tumors.
Mitomycin is an alkylating agent that works by cross-linking DNA strands, which prevents DNA replication and transcription. This inhibits cell division and leads to cell death, particularly affecting rapidly proliferating cancer cells.
Administered intravenously or topically depending on indication. Common side effects include bone marrow suppression (myelosuppression), nausea, vomiting, and kidney toxicity. Requires regular blood count monitoring during treatment. May cause cumulative bone marrow toxicity with repeated doses.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy