Mitotane
Mitotane is an antineoplastic medication primarily used to treat inoperable adrenal cortical carcinoma. It works by directly suppressing the adrenal cortex and modifying the peripheral metabolism of steroids, reducing corticosteroid production. This medication is specifically indicated for cases where surgical removal of the adrenal tumor is not possible.
An adrenal cytotoxic agent used to treat inoperable adrenal cortical carcinoma by suppressing adrenal cortex function and steroid metabolism.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- L01XX23
- RxNorm
- 7004
- Generic
- Mitotane
- Class
- atc-l01
- Brands
- Lysodren
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of inoperable adrenal cortical carcinoma (adrenocortical cancer) when surgical resection is not feasible
Adrenal cytotoxic agent that directly suppresses the adrenal cortex and modifies peripheral steroid metabolism, reducing 17-hydroxycorticosteroid levels
Known adrenal cytotoxic agent with incompletely understood mechanism of action; requires careful monitoring of steroid levels and adrenal function during treatment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy