Moexipril
Moexipril is an ACE inhibitor used to treat high blood pressure (hypertension). It works by relaxing blood vessels, making it easier for the heart to pump blood. It may be prescribed alone or in combination with other blood pressure medications.
Moexipril is an ACE inhibitor that lowers blood pressure by relaxing blood vessels.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- C09AA13
- RxNorm
- 30131
- Generic
- Moexipril
- Class
- atc-c09
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 500mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 250mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 400mg daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
8 groupspregnancy
first trimesteravoid if possible
avoid use during pregnancy unless benefits outweigh risks, particularly in first trimester
regular fetal monitoring
Use of this medication in this population requires careful consideration of risks and benefits.
pregnancy
second third trimestercontraindicated
do not use during second and third trimesters - associated with fetal renal failure, oligohydramnios, and death
immediate discontinuation if pregnancy suspected, fetal ultrasound for renal function
Use of this medication in this population requires careful consideration of risks and benefits.
lactation
breastfeedingavoid
do not use during breastfeeding - moexipril passes into breast milk
monitor infant for hypotension
Use of this medication in this population requires careful consideration of risks and benefits.
geriatric
elderlystart at low dose (3.75 mg once daily)
use with caution in patients over 65 years, start at lowest effective dose and titrate slowly
monitor blood pressure, renal function, and serum potassium regularly
Use with caution and monitor for adverse effects.
pediatric_age
children adolescentsnot recommended
not recommended for use in children and adolescents under 18 years due to lack of safety and efficacy data
not applicable
Use of this medication in this population requires careful consideration of risks and benefits.
renal_impairment
mild to moderatereduce dose, monitor closely
use with caution in patients with creatinine clearance 30-80 mL/min - start at low dose (3.75 mg daily) and titrate based on response
monitor renal function (serum creatinine, BUN) and serum potassium regularly
Use with caution and monitor for adverse effects.
renal_impairment
severecontraindicated or use with extreme caution
use with extreme caution or avoid in patients with creatinine clearance <30 mL/min - close monitoring required if used
frequent monitoring of renal function and potassium levels, consider alternative therapy
Use of this medication in this population requires careful consideration of risks and benefits.
hepatic_impairment
mild to moderatestart at low dose
use with caution in patients with mild to moderate hepatic impairment - moexipril is a prodrug activated in liver
monitor blood pressure response and liver function tests
Use with caution and monitor for adverse effects.
Statistics and clinical data
FDA approval year
FDA approval year for Moexipril
Drug class
Angiotensin-converting enzyme inhibitor class
Common uses
Primary therapeutic indication
Mechanism of action
Pharmacological mechanism
Moexipril is primarily used to treat essential hypertension (high blood pressure without an identifiable cause). It may also help protect kidney function in certain patients.
As an ACE inhibitor, Moexipril blocks the angiotensin-converting enzyme, which reduces the production of angiotensin II—a substance that causes blood vessels to narrow. This results in vasodilation and decreased blood pressure.
Common side effects include dry cough, dizziness, and headache. Moexipril should not be used during pregnancy as it may harm the fetus. Patients with a history of angioedema or those taking aliskiren should use this medication with caution. Regular monitoring of kidney function and blood pressure is recommended during treatment.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy