Molindone
Molindone is a typical antipsychotic medication historically used to manage symptoms of schizophrenia and other psychotic disorders. It helps reduce positive symptoms such as hallucinations, delusions, and disorganized thinking by affecting dopamine activity in the brain. This medication has largely been superseded by newer atypical antipsychotics and may not be readily available in many countries.
Molindone is an older antipsychotic used to treat schizophrenia and psychotic symptoms by blocking dopamine receptors.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- N05AE02
- RxNorm
- 7019
- Generic
- Molindone
- Class
- atc-n05
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Molindone was primarily prescribed for the treatment of schizophrenia and related psychotic disorders, helping to manage positive symptoms like hallucinations and delusions. It may have been used in cases where patients did not respond well to other antipsychotic medications.
As a typical antipsychotic, molindone works by blocking dopamine D2 receptors in the brain, which helps reduce the overactive dopamine signaling associated with psychotic symptoms. This dopamine antagonism is the primary mechanism responsible for its antipsychotic effects.
Molindone has been discontinued in many countries and is rarely prescribed today. Common side effects may include extrapyramidal symptoms (such as stiffness and tremors), sedation, and weight changes. Due to its older profile and availability concerns, healthcare providers typically prefer newer antipsychotic options with potentially fewer side effects. Always consult current prescribing information as this medication's status may vary by region.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy