Difenoxin/Atropine
Motofen is a brand-name combination medication containing difenoxin and atropine, used to treat acute and functional diarrhea in adults. The difenoxin component slows intestinal motility to reduce diarrhea frequency, while atropine discourages misuse of the medication.
Motofen is a prescription antidiarrheal combination medication used to treat acute diarrhea in adults.
Key facts at a glance
- RxNorm
- 218445
- Generic
- Motofen
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of acute diarrhea and functional diarrhea in adults when simpler antidiarrheal measures are insufficient.
Difenoxin, an opioid receptor agonist related to meperidine, acts locally on the GI tract to slow intestinal motility and reduce fluid secretion. Atropine is added in small amounts to deter misuse.
Motofen is available only by prescription. It may cause drowsiness or dizziness; patients should avoid operating machinery or driving until they know how the medication affects them. This medication should not be used in patients with certain GI conditions (obstruction, severe IBD) or in children. Patients should stay well-hydrated during treatment. Use should be limited to short-term therapy.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy