Ibuprofen
Motrin PM is a combination medication that pairs ibuprofen, an NSAID pain reliever, with diphenhydramine, a sedating antihistamine. It is designed for adults who need relief from minor aches and pains while also experiencing occasional sleeplessness. The medication is available over-the-counter for short-term use.
Motrin PM is an over-the-counter nighttime pain reliever that combines ibuprofen with a sleep aid for temporary relief of minor aches with occasional sleeplessness.
Key facts at a glance
- RxNorm
- 895656
- Generic
- Motrin Pm
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Motrin PM is used to temporarily relieve minor aches and pains such as headache, muscle aches, backache, minor arthritis pain, toothache, and menstrual cramps, particularly when accompanied by occasional sleeplessness. It is intended for short-term use in adults.
The ibuprofen component works by reducing hormones that cause inflammation and pain in the body. The diphenhydramine component is an antihistamine that produces drowsiness, helping individuals fall asleep more easily while the pain-relieving effects address their discomfort.
This medication should not be used in children under 12 years old without consulting a healthcare provider. It may cause drowsiness, so alcohol and activities requiring alertness should be avoided. Those with stomach ulcers, bleeding disorders, kidney problems, or who are pregnant should consult a doctor before use. Do not take with other products containing ibuprofen or diphenhydramine.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy