Naloxegol
Movantik is a prescription medication used to treat opioid-induced constipation (OIC) in adults with chronic non-cancer pain. It belongs to a class of drugs called peripherally-acting mu-opioid receptor antagonists (PAMORAs) and works by blocking the constipating effects of opioids in the gastrointestinal tract while helping to maintain opioid pain relief.
Movantik treats opioid-induced constipation by blocking opioid effects in the gut while preserving pain relief.
Key facts at a glance
- RxNorm
- 1551918
- Generic
- Movantik
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Movantik is FDA-approved for the treatment of opioid-induced constipation (OIC) in adults with chronic non-cancer pain who are taking opioid medications. It is specifically indicated for patients who have not responded adequately to other laxative treatments.
Movantik contains naloxegol, a peripherally-acting mu-opioid receptor antagonist. It works by binding to mu-opioid receptors in the gastrointestinal tract, blocking the constipating effects of opioid medications while keeping the opioid pain-relieving effects intact in the central nervous system.
Movantik is taken orally once daily on an empty stomach. Patients should avoid grapefruit and grapefruit juice. Common side effects may include gastrointestinal symptoms such as diarrhea, abdominal pain, and nausea. Patients with known or suspected gastrointestinal obstruction should not use this medication. Always consult a healthcare provider before starting treatment.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy