Muromonab-Cd3
Muromonab-CD3 (Orthoclone OKT3) is a murine monoclonal antibody that targets the CD3 antigen on T lymphocytes, effectively removing them from circulation. It was historically used as an immunosuppressant to prevent and treat acute rejection in solid organ transplant recipients, particularly kidney transplants. Due to significant side effects including cytokine release syndrome and the availability of newer agents, its use has declined substantially and it is no longer widely available.
Muromonab-CD3 is an immunosuppressant monoclonal antibody historically used to prevent organ transplant rejection by depleting T lymphocytes.
Key facts at a glance
- ATC
- L04AG01
- RxNorm
- 42405
- Generic
- Muromonab-Cd3
- Class
- atc-l04
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Acute rejection episodes following solid organ transplantation, particularly renal (kidney) transplants. It was used for both treatment of acute rejection and in some cases for prophylactic immunosuppression.
Muromonab-CD3 is a monoclonal antibody that binds specifically to the CD3 epsilon chain of the T-cell receptor complex on mature T lymphocytes. This binding opsonizes T cells for removal from circulation, effectively depleting circulating T lymphocyte numbers and suppressing the immune response responsible for transplant rejection.
Muromonab-CD3 is a murine (mouse-derived) protein and can cause human anti-mouse antibody responses. It carries a black box warning for severe cytokine release syndrome and increased risk of infections and malignancies. Premedication with corticosteroids, acetaminophen, and antihistamines is required. Due to its side effect profile and availability of safer alternatives, use has been largely discontinued in most countries.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy