Metreleptin
Myalept is a synthetic leptin analog used to treat metabolic complications associated with generalized lipodystrophy, a rare disorder characterized by loss of body fat and critically low leptin levels. This injectable medication helps improve metabolic parameters including blood sugar control and triglyceride levels by replacing the deficient hormone.
Myalept is a leptin replacement therapy for patients with generalized lipodystrophy to manage metabolic complications.
Key facts at a glance
- RxNorm
- 1491630
- Generic
- Myalept
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Myalept is indicated for the treatment of generalized lipodystrophy, including both congenital (Berardinelli-Seip) and acquired forms. It is used to treat metabolic complications such as diabetes, hypertriglyceridemia, and insulin resistance associated with leptin deficiency.
Myalept contains metreleptin, a recombinant analog of human leptin that binds to and activates leptin receptors. This helps regulate appetite, food intake, energy expenditure, and glucose metabolism by mimicking the effects of naturally produced leptin.
Myalept carries a boxed warning for risk of neutralising antibodies and lymphoma. It requires a restricted prescribing program due to these safety concerns. Regular monitoring of blood counts, liver function, and metabolic parameters is recommended during treatment. The medication is administered as a subcutaneous injection.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy