Gemtuzumab Ozogamicin
Mylotarg (gemtuzumab ozogamicin) is a targeted therapy used to treat acute myeloid leukemia (AML). It is a monoclonal antibody-drug conjugate that delivers chemotherapy directly to cancer cells expressing the CD33 protein. The medication is used in adults and pediatric patients with newly diagnosed or relapsed/refractory CD33-positive AML.
Mylotarg is a CD33-targeted antibody-drug conjugate used to treat certain types of acute myeloid leukemia in adults and children.
Key facts at a glance
- RxNorm
- 261585
- Generic
- Mylotarg
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Mylotarg is indicated for the treatment of adults with newly diagnosed CD33-positive acute myeloid leukemia (AML), as well as for adults and pediatric patients with relapsed or refractory CD33-positive AML.
Mylotarg is a monoclonal antibody-drug conjugate that binds to the CD33 antigen on the surface of AML cells. Once bound, it delivers a cytotoxic agent (calicheamicin) directly into the cell, causing DNA damage and cell death.
Mylotarg is administered via intravenous infusion. Common side effects include fever, nausea, low blood counts, and liver problems. Serious risks include severe liver toxicity and veno-occlusive disease/sinusoidal obstruction syndrome. Treatment should be supervised by healthcare professionals experienced in chemotherapy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy