Nabumetone
Nabumetone is a nonsteroidal anti-inflammatory drug (NSAID) used to treat osteoarthritis and rheumatoid arthritis. It is a prodrug that is converted in the liver to its active form, which reduces inflammation, pain, and joint swelling. Nabumetone is unique among NSAIDs as its inactive parent compound minimizes gastric irritation.
Nabumetone is an NSAID prodrug used to relieve arthritis pain and inflammation.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- M01AX01
- RxNorm
- 31448
- Generic
- Nabumetone
- Class
- atc-m01
- Brands
- Relafen
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- suspension, tablet, solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of osteoarthritis and rheumatoid arthritis, providing relief from pain, stiffness, and swelling associated with these conditions.
Nabumetone is a prodrug converted in the liver to an active compound that inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis and thereby decreasing inflammation and pain.
Like other NSAIDs, nabumetone may increase risk of cardiovascular events, gastrointestinal bleeding, and kidney problems. It should be avoided during late pregnancy. Patients with aspirin or NSAID allergies should not use this medication.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy