Nadofaragene Firadenovec
Nadofaragene firadenovec is a gene therapy used to treat certain types of bladder cancer in adults. It works by delivering a gene that instructs bladder cells to produce interferon-alfa 2b, a protein that helps the immune system fight cancer, directly into the bladder. This treatment is specifically used for non-muscle invasive bladder cancer that has not responded to standard BCG therapy.
A gene therapy that treats bladder cancer by causing bladder cells to produce interferon, enabling the immune system to attack cancer cells locally.
Key facts at a glance
- ATC
- L01XL10
- RxNorm
- 2644436
- Generic
- Nadofaragene Firadenovec
- Class
- atc-l01
- Brands
- Adstiladrin
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- suspension
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Treatment of adults with non-muscle invasive bladder cancer (NMIBC) who are unresponsive to or cannot receive BCG therapy.
Delivers a copy of the human interferon-alfa 2b gene directly into bladder cells using a non-replicating adenoviral vector. The transduced cells then produce interferon locally, exerting antitumor effects against cancer cells in the bladder.
Administered as an intravesical instillation directly into the bladder via catheter. As a non-replicating vector, it does not replicate in the body. Patients should be monitored for potential immune responses and local adverse effects. Sexual partners should use precautions as viral DNA may be shed.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy