Nafarelin
Nafarelin is a synthetic gonadotropin-releasing hormone (GnRH) agonist that works by initially stimulating, then suppressing the pituitary gland's release of gonadotropins, leading to decreased production of sex hormones. It is primarily used to treat moderate to severe endometriosis in women and central precocious puberty in children. The medication is administered as a nasal spray and works by causing reversible suppression of the hypothalamic-pituitary-gonadal axis.
Nafarelin is a GnRH agonist nasal spray used for endometriosis and central precocious puberty that works by suppressing sex hormone production.
Key facts at a glance
- ATC
- H01CA02
- RxNorm
- 28656
- Generic
- Nafarelin
- Class
- atc-h01
- Brands
- Synarel
- Availability
- rx
- Lactation
- unknown
- Routes
- nasal
- Forms
- spray
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of moderate to severe endometriosis in women and central precocious puberty in children. Occasionally used in assisted reproduction protocols.
As a GnRH agonist, it initially stimulates then causes downregulation of GnRH receptors in the pituitary gland, leading to suppressed release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which results in decreased sex hormone production.
Administered via nasal spray, typically twice daily. Common side effects include hypoestrogenic symptoms such as hot flashes, vaginal dryness, and decreased libido. Should not be used during pregnancy. Long-term use may affect bone density. Treatment duration for endometriosis is typically limited to 6 months.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy