Naldemedine
Naldemedine is a peripherally-acting opioid receptor antagonist used to treat opioid-induced constipation in adults with chronic non-cancer pain by blocking opioid receptors.
Naldemedine treats constipation caused by opioid pain medications by blocking their constipating effects in the gut.
Key facts at a glance
- ATC
- A06AH05
- RxNorm
- 1876597
- Generic
- Naldemedine
- Class
- atc-a06
- Brands
- Symproic
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of opioid-induced constipation (OIC) in adults taking opioids for chronic non-cancer pain who have not responded adequately to other laxatives.
Naldemedine is a peripherally-acting mu-opioid receptor antagonist with activity at mu-, delta-, and kappa-opioid receptors. By blocking opioid receptors in the gastrointestinal tract, it reduces the inhibitory effects of opioids on gut motility and secretions, thereby improving bowel function.
Should not be used in patients with known or suspected bowel obstruction. May cause diarrhea, abdominal pain, or vomiting. Efficacy is dependent on continued opioid use. Not indicated for constipation unrelated to opioid use. Use with caution in patients at risk for gastrointestinal perforation.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy