Naloxegol
Naloxegol is a peripherally-acting mu-opioid receptor antagonist (PAMORA) used to treat opioid-induced constipation in adults with chronic non-cancer pain.
Naloxegol is a constipation treatment for patients on chronic opioid therapy that works by blocking opioid effects in the gut while preserving pain relief.
Key facts at a glance
- ATC
- A06AH03
- RxNorm
- 1551777
- Generic
- Naloxegol
- Class
- atc-a06
- Brands
- Movantik
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain who have had an inadequate response to laxatives.
Naloxegol is a peripherally-acting mu-opioid receptor antagonist that selectively blocks opioid binding at mu-opioid receptors in the gastrointestinal tract, reducing the constipating effects of opioids without significantly affecting central nervous system opioid analgesia.
Contraindicated in patients with known or suspected gastrointestinal obstruction. May cause abdominal pain, diarrhea, and other GI symptoms. Use with caution in patients at risk for GI perforation. May precipitate opioid withdrawal in patients dependent on opioids if absorbed systemically.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy