Naphazoline
Naphazoline is a topical decongestant that provides relief from nasal congestion and eye redness by narrowing blood vessels in the nasal passages and conjunctiva. It is commonly used for temporary relief of allergic rhinitis, sinusitis, and minor eye irritation. This medication is available over-the-counter in nasal spray and eye drop formulations.
Naphazoline is a topical decongestant that relieves nasal congestion and eye redness by constricting blood vessels.
Key facts at a glance
- ATC
- R01A
- RxNorm
- unknown
- Generic
- Naphazoline
- Class
- atc-r01
- Brands
- Advanced Eye Relief Redness Instant Relief, AK-Con, Naphcon A, Opcon-A, Privine, All Clear
- Availability
- otc
- Pregnancy
- C
- Lactation
- caution
- Half-life (h)
- 3
- Onset (min)
- 5
- Duration (h)
- 6
- Routes
- nasal, ophthalmic
- Forms
- nasal spray, nasal gel, ophthalmic solution, eye drops, ophthalmic ointment
- Regions
- United States, United Kingdom, Canada, Australia, Europe, India
- Monitoring
- blood pressure, heart rate
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of nasal congestion associated with colds, allergies, and sinusitis; relief of eye redness and minor eye irritation due to irritants or allergies.
Naphazoline is an imidazoline derivative that acts as a direct-acting sympathomimetic, causing vasoconstriction of the mucosal blood vessels when applied topically, thereby reducing swelling and congestion.
Should not be used for more than 3-5 days to avoid rebound congestion or dependency. Avoid in patients with narrow-angle glaucoma, severe cardiovascular disease, or those taking MAO inhibitors. May cause local irritation, pupil dilation, or systemic effects if absorbed in excess.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy