Pentamidine Isethionate
Nebupent is a brand-name formulation of pentamidine delivered via inhalation. It is primarily used as prophylaxis against Pneumocystis jirovecii pneumonia (PJP) in immunocompromised patients, such as those with HIV/AIDS or those undergoing chemotherapy. The medication helps prevent serious lung infections in patients who cannot tolerate first-line preventive treatments.
Nebupent is an inhaled medication used to prevent Pneumocystis jirovecii pneumonia in immunocompromised patients.
Key facts at a glance
- RxNorm
- 218646
- Generic
- Nebupent
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention of Pneumocystis jirovecii pneumonia (PJP) in immunocompromised individuals, including patients with HIV/AIDS, organ transplant recipients, and those on immunosuppressive therapies. May also have off-label use for other pulmonary infections in specific clinical situations.
Pentamidine is an antiprotozoal agent that works by inhibiting DNA synthesis in susceptible organisms, including Pneumocystis jirovecii. When delivered via nebulizer, it deposits directly in the lungs to provide localized antimicrobial protection.
Nebupent is administered via inhalation using a nebulizer, typically on a monthly schedule for prophylaxis. Patients should be monitored for potential side effects including cough, bronchospasm, and rare systemic effects. Not for treatment of active PJP infection (intravenous pentamidine is used for active disease). Patients should have baseline lung function tests before initiating therapy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy