Nefazodone
Nefazodone is an antidepressant medication classified as a serotonin modulator. It works by blocking serotonin 5-HT2A receptors and inhibiting serotonin reuptake, which helps regulate mood. Due to concerns about rare but serious liver toxicity, its use has declined significantly and it is no longer widely available in many countries.
An older antidepressant (serotonin modulator) no longer commonly used due to liver toxicity concerns.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- N06AX06
- RxNorm
- 31565
- Generic
- Nefazodone
- Class
- atc-n06
- Brands
- —
- Availability
- rx
- Pregnancy
- C
- Lactation
- caution
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used for the treatment of major depressive disorder (MDD). It was sometimes used off-label for conditions like anxiety disorders and insomnia, though its use has become limited due to safety concerns.
Nefazodone works by blocking 5-HT2A serotonin receptors and inhibiting serotonin reuptake, while also having mild norepinephrine reuptake inhibition. This dual mechanism increases serotonin activity in the brain to help improve mood.
Black box warning for potential liver failure requiring transplantation. Has been discontinued by most manufacturers due to hepatotoxicity concerns. Requires liver function monitoring. May cause sedation and has fewer sexual side effects than SSRIs. Contraindicated with terfenadine, astemizole, cisapride, pimozide, or carbamazepine due to drug interactions.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy