Nefopam
Nefopam is a non-opioid analgesic medication used to treat moderate to severe acute pain, including post-operative pain, musculoskeletal conditions, and trauma-related discomfort. Unlike NSAIDs, it works through the central nervous system via multiple neurotransmitter pathways. It is commonly used in Europe and Asia as an alternative or adjunct to other analgesics for managing pain when standard options are insufficient.
Nefopam is a centrally-acting non-opioid pain reliever for moderate to severe acute pain, used when standard analgesics are inadequate.
Key facts at a glance
- ATC
- N02BG06
- RxNorm
- 7285
- Generic
- Nefopam
- Class
- atc-n02
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- solution, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Nefopam treats moderate to severe acute pain including post-operative pain, musculoskeletal disorders like back pain, trauma-related pain, and cancer pain. It is often employed when conventional analgesics prove insufficient or as part of multimodal pain management strategies.
Nefopam acts centrally in the nervous system by modulating serotonin, norepinephrine, and dopamine pathways to inhibit pain signal transmission. Unlike opioids or NSAIDs, it provides analgesia through unique neurochemical mechanisms.
Common side effects include nausea, dry mouth, dizziness, and drowsiness. It requires caution in patients with glaucoma, urinary retention, or cardiovascular conditions. Not available in all countries, including the United States.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy