Phenylephrine Hydrochloride Extended Release
Neo-Synephrine 12 Hour is a nasal decongestant spray containing phenylephrine as its active ingredient. It provides relief from nasal congestion caused by colds, allergies, or sinus infections by narrowing blood vessels in the nasal passages. This brand-name medication offers extended relief and is applied directly into the nostrils.
Neo-Synephrine 12 Hour is a nasal spray decongestant used to temporarily relieve stuffy nose from colds or allergies.
Key facts at a glance
- RxNorm
- 218667
- Generic
- Neo-Synephrine 12 Hour
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of nasal congestion associated with the common cold, hay fever, or other upper respiratory allergies, sinusitis, and rhinitis. It helps reduce swelling and stuffiness in the nasal passages.
Phenylephrine is an alpha-adrenergic agonist that causes vasoconstriction (narrowing) of blood vessels in the nasal mucosa, which reduces swelling and congestion, allowing for easier breathing through the nose.
For topical nasal use only. Should not be used for more than 3 consecutive days to avoid rebound congestion (rhinitis medicamentosa). Consult a healthcare provider before use if you have heart disease, high blood pressure, thyroid problems, diabetes, or difficulty urinating due to prostate enlargement. Keep out of eyes. Do not share the bottle with others to prevent contamination.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy