Nepafenac
Nepafenac is a topical ophthalmic NSAID (nonsteroidal anti-inflammatory drug) administered as eye drops to reduce ocular inflammation and pain. It is primarily used following cataract surgery and other ocular procedures. The medication works by inhibiting cyclooxygenase enzymes, thereby decreasing prostaglandin production in the eye.
A topical eye drop NSAID used to reduce inflammation and pain after ocular surgery.
Key facts at a glance
- ATC
- S01BC10
- RxNorm
- 298665
- Generic
- Nepafenac
- Class
- atc-s01
- Brands
- Ilevro, Nevanac
- Availability
- rx
- Pregnancy
- C
- Lactation
- caution
- Routes
- ophthalmic
- Forms
- suspension
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of postoperative inflammation and pain following cataract surgery and other ophthalmic procedures. May also be used for seasonal allergic conjunctivitis and ocular discomfort.
After topical ocular administration, nepafenac penetrates the cornea where it is converted by ocular tissue hydrolases to its active form, amfenac. Both nepafenac and amfenac inhibit cyclooxygenase (prostaglandin H synthase), blocking prostaglandin synthesis and reducing inflammatory responses.
For topical ophthalmic use only. May cause blurred vision or eye irritation. Avoid contact with soft contact lenses. Use with caution in patients with bleeding tendencies or those taking anticoagulants. Not recommended for prolonged use without medical supervision.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy