Neratinib
Neratinib is an irreversible tyrosine kinase inhibitor that targets HER2, EGFR, and HER4 receptors. It is primarily used as extended adjuvant therapy for adults with early-stage HER2-positive breast cancer following trastuzumab-based treatment. By blocking these signaling pathways, it helps prevent cancer recurrence.
Neratinib is a targeted therapy for HER2-positive breast cancer that works by irreversibly inhibiting HER2 and related growth factor receptors.
Key facts at a glance
- ATC
- L01EH02
- RxNorm
- 1940643
- Generic
- Neratinib
- Class
- atc-l01
- Brands
- Nerlynx
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Extended adjuvant treatment of early-stage HER2-positive breast cancer in adults who have previously received trastuzumab-based therapy. It is typically started within one year of completing trastuzumab treatment.
Neratinib irreversibly binds to and inhibits EGFR, HER2, and HER4 tyrosine kinases. This blocks autophosphorylation of these receptors and inhibits downstream signaling through MAPK and AKT pathways, which are involved in tumor cell proliferation and survival.
Common side effects include diarrhea (often severe), nausea, vomiting, and fatigue. Patients typically receive antidiarrheal prophylaxis when starting treatment. Liver function monitoring is recommended. May cause fetal harm if used during pregnancy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy