Afoxolaner and Milbemycin Oxime
Nexgard Combo is a prescription topical parasiticide for dogs that provides broad-spectrum protection against fleas, ticks, and other common parasites. This monthly treatment is applied to the skin and is indicated for use in dogs and puppies of specified ages and weights.
Nexgard Combo is a monthly topical medication for dogs that kills and prevents fleas and ticks.
Key facts at a glance
- RxNorm
- 2636812
- Generic
- Nexgard Combo
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Nexgard Combo is indicated for the treatment and prevention of flea infestations (Ctenocephalides spp.) and tick infestations (Ixodes, Rhipicephalus, Dermacentor spp.) in dogs. It may also provide protection against ear mites and sarcoptic mange. The product is approved for dogs and puppies 8 weeks of age and older, weighing at least 1.8 lbs (0.8 kg).
Nexgard Combo contains active ingredients (including afoxolaner) that belong to the isoxazoline class of parasiticides. The medication works by disrupting the nervous system of parasites when they bite the treated dog, causing paralysis and death of the insects. The active ingredients are absorbed through the skin and distributed across the dog's body to provide ongoing protection.
Nexgard Combo is for topical use only and should be applied according to package directions. It is not for human use and should be kept out of reach of children. The product is not approved for use in cats. Some dogs may experience mild, transient skin reactions at the application site. Consult your veterinarian before use in pregnant, breeding, or lactating dogs. Do not allow recently treated dogs to groom each other.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy