Bempedoic Acid and Ezetimibe
Nexlizet is a prescription brand-name medication combining bempedoic acid and ezetimibe. It is used in adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who need additional LDL cholesterol lowering alongside diet and statin therapy. This combination works through two different mechanisms to reduce cholesterol levels.
Nexlizet is a dual-mechanism cholesterol-lowering medication combining bempedoic acid and ezetimibe for patients needing additional LDL reduction.
Key facts at a glance
- RxNorm
- 2283231
- Generic
- Nexlizet
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Nexlizet is indicated for use in adults with heterozygous familial hypercholesterolemia (HeFH) or established atherosclerotic cardiovascular disease (ASCVD) who require additional LDL cholesterol lowering when diet and maximum tolerated statin therapy alone is inadequate.
Nexlizet combines two cholesterol-lowering agents: bempedoic acid inhibits ATP citrate lyase in the liver, reducing cholesterol synthesis, while ezetimibe inhibits the NPC1L1 transporter in the intestinal wall, blocking cholesterol absorption. Together they provide complementary LDL reduction.
Nexlizet may cause elevated liver enzymes and has been associated with tendon rupture risk. It is contraindicated in pregnancy. Common side effects include upper respiratory infections, muscle spasms, and back pain. Patients should maintain a cholesterol-lowering diet during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy