Nicorandil
Nicorandil is a medication used primarily to prevent and treat angina (chest pain) by improving blood flow to the heart muscle. It works by dilating blood vessels through two mechanisms: releasing nitric oxide and opening potassium channels. This medication is typically prescribed for patients with chronic stable angina who have not responded adequately to other treatments.
Nicorandil is a vasodilator used to prevent angina by improving blood flow to the heart through dual mechanisms of nitric oxide release and potassium channel activation.
Key facts at a glance
- ATC
- C01DX16
- RxNorm
- 31748
- Generic
- Nicorandil
- Class
- atc-c01
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Nicorandil is indicated for the prevention and treatment of stable angina pectoris, particularly in patients who have an inadequate response to or are intolerant of other anti-anginal medications such as beta-blockers, calcium channel blockers, or nitrates.
Nicorandil works through two complementary mechanisms: it releases nitric oxide, which activates guanylate cyclase and causes smooth muscle relaxation and vasodilation, and it opens ATP-sensitive potassium channels, leading to hyperpolarization of vascular smooth muscle cells. This dual action causes dilation of both coronary arteries (improving oxygen supply) and systemic veins/arteries (reducing cardiac workload).
Common side effects include headache, flushing, dizziness, and hypotension due to vasodilation. A notable adverse effect is the development of oral, GI, or skin ulcers. Nicorandil should be used with caution in patients with low blood pressure, heart failure, or those taking phosphodiesterase-5 inhibitors (e.g., sildenafil) due to risk of severe hypotension. It is not indicated for acute angina attacks.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy