Nifurtimox
Nifurtimox is an antiprotozoal medication used to treat certain parasitic infections caused by Trypanosoma species. It is primarily indicated for Chagas disease (American trypanosomiasis) and African sleeping sickness (human African trypanosomiasis). The drug works by generating toxic free radicals within the parasite that damage its cellular components and lead to its destruction.
Nifurtimox is an antiprotozoal drug used to treat Chagas disease and African sleeping sickness by generating toxic metabolites that kill the parasites.
Key facts at a glance
- ATC
- P01CC01
- RxNorm
- 7421
- Generic
- Nifurtimox
- Class
- atc-p01
- Brands
- Lampit
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Nifurtimox is used to treat Chagas disease (American trypanosomiasis) caused by Trypanosoma cruzi and African sleeping sickness (human African trypanosomiasis) caused by Trypanosoma brucei. It is typically used in acute and early chronic phases of Chagas disease and may be used in combination with other agents for certain forms of sleeping sickness.
Nifurtimox is a nitrofuran derivative that enters trypanosome parasites and undergoes reduction by their metabolic pathways. This reduction process generates reactive oxygen species and free radicals that damage parasite proteins, lipids, and DNA, ultimately leading to parasite death.
Common side effects may include gastrointestinal symptoms such as nausea, vomiting, and abdominal pain, as well as neurological effects like headache, dizziness, and peripheral neuropathy. Treatment typically requires extended duration, often several weeks to months. Patients should be monitored for adverse reactions throughout therapy. The medication is generally used under medical supervision in areas where these parasitic diseases are endemic.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy