Nintedanib
Nintedanib is an antineoplastic medication classified as a multiple tyrosine kinase inhibitor. It is primarily prescribed for the treatment of idiopathic pulmonary fibrosis (IPF) and other progressive fibrosing interstitial lung diseases, helping to slow disease progression. The medication works by blocking signals involved in fibroblast proliferation and tissue fibrosis.
Nintedanib is a tyrosine kinase inhibitor used to treat certain fibrotic lung diseases by slowing disease progression.
Key facts at a glance
- ATC
- L01EX09
- RxNorm
- 1592737
- Generic
- Nintedanib
- Class
- atc-l01
- Brands
- Ofev
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Nintedanib is approved for treating idiopathic pulmonary fibrosis (IPF), other progressive fibrosing interstitial lung diseases (PF-ILDs), and systemic sclerosis-associated interstitial lung disease (SSc-ILD). It is also used in combination with other medications for certain types of lung cancer.
Nintedanib inhibits multiple receptor tyrosine kinases (RTKs) including platelet-derived growth factor receptors (PDGFR α/β), fibroblast growth factor receptors (FGFR 1-3), and vascular endothelial growth factor receptors (VEGFR). By blocking these pathways involved in fibroblast proliferation, angiogenesis, and tissue remodeling, it reduces fibrotic processes in the lungs.
Common side effects include diarrhea, nausea, abdominal pain, liver enzyme elevations, and vomiting. Regular liver function monitoring is required during treatment. Nintedanib may cause fetal harm and is contraindicated during pregnancy. Patients with moderate to severe hepatic impairment should use with caution.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy