Nirogacestat
Nirogacestat is a gamma-secretase inhibitor used in cancer treatment that works by blocking the proteolytic activation of the Notch receptor. By inhibiting Notch signaling, it prevents the activation of pathways that contribute to tumor growth when this receptor is dysregulated. It is classified as an antineoplastic (ATC-L01) agent.
Nirogacestat is an anticancer drug that inhibits gamma-secretase to block Notch signaling and prevent tumor growth.
Key facts at a glance
- ATC
- L01XX81
- RxNorm
- 2670631
- Generic
- Nirogacestat
- Class
- atc-l01
- Brands
- Ogsiveo
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Nirogacestat is used to treat conditions associated with dysregulated Notch signaling, including desmoid tumors (aggressive fibromatosis). It is prescribed as an antineoplastic therapy for patients with progressive, unresectable tumors where Notch pathway activation contributes to disease progression.
Nirogacestat inhibits gamma-secretase, an enzyme responsible for the proteolytic activation of Notch receptors. By blocking this activation, the drug prevents Notch-mediated signaling cascades that drive tumor cell proliferation and survival. This targeted approach helps control tumor growth in cancers driven by Notch dysregulation.
As a targeted therapy, nirogacestat may cause side effects related to Notch inhibition. Patients should be monitored for gastrointestinal effects, fatigue, and other adverse reactions. Treatment should be supervised by an oncologist experienced with gamma-secretase inhibitors.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy