Desmopressin Acetate
Nocdurna is a brand-name prescription medication containing desmopressin, a synthetic form of an antidiuretic hormone. It is primarily used to treat nocturia (excessive urination at night) in adults who produce excessive amounts of urine during sleep hours. The medication works by helping the kidneys reduce urine production, allowing for uninterrupted sleep.
Nocdurna is a sublingual tablet used to reduce nighttime urination in adults with nocturia caused by excessive nighttime urine production.
Key facts at a glance
- RxNorm
- 2048573
- Generic
- Nocdurna
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Nocdurna is approved for the treatment of nocturia in adults, specifically when caused by nocturnal polyuria (overproduction of urine at night). It is not indicated for primary nocturnal enuresis (bedwetting) or other causes of nighttime urination.
Desmopressin, the active ingredient, mimics the action of naturally occurring vasopressin (antidiuretic hormone). It binds to V2 receptors in the kidney's collecting ducts, promoting water reabsorption and reducing urine output during the night.
Nocdurna is taken once daily at bedtime by placing the tablet under the tongue. Patients should limit fluid intake 1 hour before and 8 hours after dosing to reduce the risk of hyponatremia (low sodium levels). It is contraindicated in patients with hyponatremia, SIADH, heart failure, or renal impairment. Regular monitoring of sodium levels may be required. Common side effects may include dry mouth, headache, and dizziness.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy