Nogapendekin Alfa Inbakicept
Nogapendekin alfa inbakicept-pmln is an IL-15 receptor agonist classified as an immunostimulant. It works by activating the IL-15 signaling pathway, which plays a crucial role in immune system regulation and the proliferation of natural killer (NK) cells and T lymphocytes. This medication is being investigated for use in cancer immunotherapy, where it aims to enhance the body's immune response against tumor cells.
An IL-15 receptor agonist immunostimulant being developed for cancer immunotherapy that activates and expands immune cells.
Key facts at a glance
- ATC
- L03AC03
- RxNorm
- 2682678
- Generic
- Nogapendekin Alfa Inbakicept
- Class
- atc-l03
- Brands
- Anktiva
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 400 mcg once weekly
- Maximum
- consult physician
- Frequency
- weekly for 12 weeks induction, then maintenance
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- not established
- Maximum
- consult physician
- Frequency
- not applicable
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 400 mcg once weekly
- Maximum
- consult physician
- Frequency
- weekly for 12 weeks induction, then maintenance
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
12 groupspregnancy
first trimesteravoid if possible
avoid use during pregnancy unless benefits significantly outweigh risks
regular fetal monitoring and ultrasound assessments
Use of this medication in this population requires careful consideration of risks and benefits.
pregnancy
second trimesteruse only if benefits outweigh risks
use only when clearly needed with careful risk-benefit assessment
routine prenatal monitoring
Use with caution and monitor for adverse effects.
pregnancy
third trimesteruse only if benefits outweigh risks
use only when clearly needed, consider timing of administration
fetal monitoring and assessment of labor
Use with caution and monitor for adverse effects.
lactation
n aavoid or discontinue breastfeeding
discontinue breastfeeding during treatment and for at least 30 days after last dose
monitor infant for signs of immune system effects
geriatric
n ano specific dose adjustment required but monitor closely
use with caution due to potential age-related decline in immune function
monitor renal function and overall treatment response
Use with caution and monitor for adverse effects.
pediatric_age
children under 18not applicable
not approved for use in pediatric patients
n_a
Use of this medication in this population requires careful consideration of risks and benefits.
renal_impairment
mildno specific dose adjustment required
use with caution, monitor renal function
baseline and periodic renal function monitoring
Use with caution and monitor for adverse effects.
renal_impairment
moderateconsider dose adjustment based on clinical response
use with caution, more frequent monitoring recommended
regular monitoring of renal function and treatment response
Use with caution and monitor for adverse effects.
renal_impairment
severeconsider dose reduction and extended dosing intervals
use with caution in severe impairment, individualize therapy
frequent renal function monitoring and adverse event assessment
Use with caution and monitor for adverse effects.
hepatic_impairment
mildno specific dose adjustment required
use with caution, monitor hepatic function
baseline and periodic liver function tests
Use with caution and monitor for adverse effects.
hepatic_impairment
moderateconsider dose adjustment based on clinical response
use with caution, monitor liver function tests more frequently
regular hepatic function monitoring
Use with caution and monitor for adverse effects.
hepatic_impairment
severeuse with significant dose reduction
use with extreme caution in severe hepatic impairment
frequent hepatic function monitoring and adverse event assessment
Use with caution and monitor for adverse effects.
Statistics and clinical data
Drug class
Immunotherapy agent classification
FDA approval year
FDA approval date for Anktiva
Indication
Therapeutic indication for Anktiva with BCG
Mechanism of action
Immunomodulatory mechanism
Investigational use in cancer immunotherapy, particularly being studied for the treatment of certain malignancies where immune stimulation may provide therapeutic benefit.
As an IL-15 receptor agonist, this medication binds to and activates the IL-15 receptor complex (composed of the common gamma chain, beta chain, and IL-15 receptor alpha subunit), triggering intracellular signaling that promotes the activation, proliferation, and survival of NK cells and T lymphocytes, thereby enhancing immune responses against cancer cells.
As an immunostimulant, it may cause immune-related adverse effects. Patients should be monitored for cytokine release syndrome and other immune-mediated reactions. Clinical monitoring and appropriate management of immune-related toxicities is essential during treatment.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy