Orphenadrine Citrate and Aspirin
Norgesic is a combination medication containing orphenadrine citrate (a muscle relaxant), aspirin (an analgesic and anti-inflammatory), and caffeine. It is prescribed for the relief of acute painful musculoskeletal conditions, typically as part of a broader treatment plan that may include rest and physical therapy.
A combination muscle relaxant and analgesic used to treat acute musculoskeletal pain and discomfort.
Key facts at a glance
- RxNorm
- 218776
- Generic
- Norgesic
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of acute, painful musculoskeletal conditions such as muscle strains, sprains, and tension headaches. Used as adjunctive therapy alongside rest, physical therapy, and other supportive measures.
Orphenadrine citrate acts centrally on the skeletal muscles to reduce muscle spasms and tension. Aspirin provides analgesic and anti-inflammatory effects, while caffeine enhances pain relief and acts as a mild stimulant to counteract drowsiness.
Contains aspirin, so contraindicated in patients with aspirin allergy, bleeding disorders, or those taking anticoagulants. May cause drowsiness or dizziness; alcohol should be avoided. Not recommended for use in patients with glaucoma, urinary retention, or certain cardiac conditions. Should be used cautiously in elderly patients.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy