Droxidopa
Northera (droxidopa) is a prescription medication used to treat neurogenic orthostatic hypotension (NOH), a condition causing dangerously low blood pressure upon standing due to autonomic nervous system dysfunction. It is commonly prescribed for patients with Parkinson's disease, multiple system atrophy, or pure autonomic failure.
Northera treats low blood pressure upon standing in patients with autonomic nervous system disorders by increasing norepinephrine levels to raise blood pressure.
Key facts at a glance
- RxNorm
- 1490027
- Generic
- Northera
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Neurogenic orthostatic hypotension (NOH), including orthostatic dizziness, lightheadedness, or syncope associated with Parkinson's disease, multiple system atrophy, pure autonomic failure, dopamine beta-hydroxylase deficiency, and non-diabetic autonomic neuropathy.
Droxidopa is a prodrug that crosses the blood-brain barrier and is converted to norepinephrine (noradrenaline) in the body. The increased norepinephrine acts on alpha-adrenergic receptors to cause vasoconstriction, thereby raising blood pressure when standing.
May cause supine hypertension (elevated blood pressure when lying down) which requires monitoring. Common side effects include headache, dizziness, nausea, and fatigue. Should be taken during the day upon waking and at least 3 hours before bedtime. Patients with heart disease, severe renal impairment, or history of heart failure should use with caution. May interact with other blood pressure medications.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy