Novobiocin
Novobiocin is an aminocoumarin antibiotic historically used to treat serious staphylococcal infections, particularly those caused by organisms resistant to other antibiotics. It was typically reserved for severe infections when first-line treatments failed, though its use has diminished significantly due to availability of safer alternatives and notable toxicity concerns.
Novobiocin is an older antibiotic primarily used for drug-resistant staphylococcal infections, now largely replaced by safer options.
Key facts at a glance
- RxNorm
- 7538
- Generic
- Novobiocin
- Class
- unclassified
- Brands
- Albadry
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- prefilled syringe, capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Novobiocin was primarily used to treat serious infections caused by Staphylococcus aureus, including skin and soft tissue infections, endocarditis, and osteomyelitis when caused by susceptible, drug-resistant organisms. Its use was generally reserved for hospital-acquired infections resistant to penicillins and other standard antibiotics.
Novobiocin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and transcription. By inhibiting these enzymes, the drug prevents bacteria from replicating their genetic material, ultimately leading to bacterial cell death.
Novobiocin is no longer widely available or commonly used in clinical practice. Associated side effects include hepatotoxicity (liver damage), bone marrow suppression, and gastrointestinal disturbances. The drug requires careful monitoring of liver function and blood counts during treatment. Resistance to novobiocin can develop during therapy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 31, 2026. · Read our editorial policy