Mepolizumab
Nucala (mepolizumab) is a monoclonal antibody that targets interleukin-5 (IL-5) to reduce eosinophil levels in the blood. It is prescribed for patients with severe eosinophilic asthma, eosinophilic granulomatosis with polyangiitis (EGPA), hypereosinophilic syndrome (HES), and chronic rhinosinusitis with nasal polyps. This medication is typically used when conventional therapies have not adequately controlled symptoms.
Nucala is an IL-5 inhibitor used to treat severe eosinophilic conditions by reducing eosinophil levels.
Key facts at a glance
- RxNorm
- 1720602
- Generic
- Nucala
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Nucala is indicated for the treatment of severe eosinophilic asthma (as add-on maintenance therapy), eosinophilic granulomatosis with polyangiitis (EGPA), hypereosinophilic syndrome (HES), and chronic rhinosinusitis with nasal polyps (CRSwNP) in appropriate adult patients.
Nucala is a monoclonal antibody that binds to interleukin-5 (IL-5), preventing it from binding to its receptor on eosinophil cells. By blocking IL-5, it inhibits the production, survival, and activation of eosinophils, thereby reducing eosinophil-mediated inflammation.
Nucala is administered as a subcutaneous injection, typically every 4 weeks. It should not be used to treat acute asthma symptoms or bronchospasm. Patients should be monitored for hypersensitivity reactions and infections. It is not a rescue medication and should be used as part of a comprehensive asthma management plan.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy