Pimavanserin
Nuplazid (pimavanserin) is a prescription medication specifically approved to treat hallucinations and delusions associated with Parkinson's disease psychosis. It works by targeting serotonin receptors in the brain rather than dopamine receptors, making it unique for this patient population. This medication is designed for adults experiencing psychotic symptoms that cannot be adequately managed by adjusting their Parkinson's medications.
Nuplazid is a medication used to treat hallucinations and delusions in adults with Parkinson's disease psychosis.
Key facts at a glance
- RxNorm
- 1791692
- Generic
- Nuplazid
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Nuplazid is FDA-approved specifically for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis in adults. It is not indicated for other psychotic disorders or for use in patients with dementia-related psychosis.
Nuplazid works as an inverse agonist at serotonin 5-HT2A receptors in the brain. By blocking these receptors, it helps reduce psychotic symptoms without affecting dopamine receptors, which is important since dopamine-blocking antipsychotics can worsen motor symptoms in Parkinson's disease patients.
Nuplazid may increase the risk of death in elderly patients with dementia-related psychosis and is not approved for this use. Common side effects may include swelling, nausea, and confusion. Patients should inform their doctor of all medications they're taking, as drug interactions can occur. Treatment should be regularly reassessed for ongoing need.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy